Journal of Henan Agricultural Sciences ›› 2025, Vol. 54 ›› Issue (9): 15-22.DOI: 10.15933/j.cnki.1004-3268.2025.09.002
• Reviews • Previous Articles Next Articles
ZHANG Yuyang
Received:2025-05-09
Accepted:2025-06-27
Published:2025-09-15
Online:2025-09-10
张玉杨
作者简介:张玉杨(1972-),女,河南开封人,副研究员,硕士,主要从事动物疾病防治研究。E-mail:zhangyyzhao@126.com
基金资助:CLC Number:
ZHANG Yuyang. Research Progress of Porcine Getah Virus[J]. Journal of Henan Agricultural Sciences, 2025, 54(9): 15-22.
张玉杨. 猪源盖塔病毒研究进展[J]. 河南农业科学, 2025, 54(9): 15-22.
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.hnnykx.org.cn/EN/10.15933/j.cnki.1004-3268.2025.09.002
| [1]CASALS J. International arbovirus research[J].Medical Biology,1975,53(5):249‑258. [2]FUKUNAGA Y,KUMANOMIDO T,KAMADA M. Getah virus as an equine pathogen[J].Veterinary Clinics of North America:Equine Practice,2000,16(3):605‑617. [3]LI B,WANG H Y,LIANG G D. Getah virus(alphavirus):An emerging,spreading zoonotic virus J].Pathogens,2022,11(8):945. [4]SHAO L N,NIE M C,LIU B L,et al. Isolation and characterization of a porcine getah virus strain from Sichuan Province[J]. Veterinary Sciences,2025,12(3):276. [5]MATSUMURA R,BANNAI H,NEMOTO M,et al.Genetic,phylogenetic,and serological analysis of a getah virus strain isolated from Culex tritaeniorhynchus mosquitoes in Nagasaki,Japan in 2022[J].Japanese Journal of Infectious Diseases,2025,78(2):71‑78. [6]DENG Y L,LIN Z Y,LIN R,et al. Isolation and characterization of getah virus GD2202 from mosquitoes in Foshan,China[J].Vector Borne and Zoonotic Diseases,2025,25(4):269‑276. [7]LU G,CHEN R A,SHAO R,et al. Getah virus:An increasing threat in China[J].The Journal of Infection,2020,80(3):350‑371. [8]CALISHER C H,SHOPE R E,BRANDT W,et al.Proposed antigenic classification of registered arboviruses I. Togaviridae,Alphavirus[J]. Intervirology,1980,14(5/6):229‑232. [9]WANG A J,ZHOU F,LIU C C,et al. Structure of infective Getah virus at 2. 8 Å resolution determined by cryo‑electron microscopy[J]. Cell Discovery,2022,8(1):12. [10]RUPP J C,SOKOLOSKI K J,GEBHART N N,et al.Alphavirus RNA synthesis and non‑structural protein functions[J]. The Journal of General Virology,2015,96 (9):2483‑2500. [11]RAMSEY J,MUKHOPADHYAY S. Disentangling the frames,the state of research on the alphavirus 6K and TF proteins[J].Viruses,2017,9(8):228. [12]WANG M,SUN Z Z,CUI C X,et al. Structural insights into alphavirus assembly revealed by the cryo‑EM structure of getah virus[J]. Viruses,2022,14(2):327. [13]REN T W,MO Q R,WANG Y X,et al. Emergence and phylogenetic analysis of a getah virus isolated in Southern China[J]. Frontiers in Veterinary Science,2020,7:552517. [14]HOLMES A C,BASORE K,REMONT D H,et al. A molecular understanding of alphavirus entry[J].PLoSPathogens,2020,16(10):e1008876. [15]KIM A S,DIAMOND M S. A molecular understanding of alphavirus entry and antibody protection[J].Nature Reviews Microbiology,2023,21(6):396‑407. [16]GUO Z H,JIANG Y,LI P,et al. Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in Central China[J].Frontiers in Microbiology,2025,16:1515632. [17]PAN J H,ZHANG H Q,CHEN X Q,et al. Evolutionary characterization and pathogenicity of Getah virus from pigs in Guangdong Province of China[J].Archives of Virology,2023,168(10):258. [18]HU T S,ZHENG Y,ZHANG Y,et al. Identification of a novel Getah virus by virus‑discovery‑cDNA random amplified polymorphic DNA(RAPD)[J]. BMC Microbiology,2012,12:305. [19]CHU P P,GUO H Y,ZHOU X,et al. Emergence of a novel GIII Getah virus variant in pigs in Guangdong,China,2023[J]. Microbiology Spectrum,2024,12(8):e0048324. [20]HUANG J,SONG D P,WEI J Z,et al. First report on identification and genetic characterization of Getah virus in wild boar in China[J].Frontiers in Microbiology,2025,16:1583023. [21]YANG T,LI R,HU Y,et al. An outbreak of Getah virus infection among pigs in China,2017[J].Transboundary and Emerging Diseases,2018,65(3):632‑637. [22]ASAI T,SHIBATA I,URUNO K. Susceptibility of pregnant hamster,guinea pig,and rabbit to the transplacental infection of Getah virus[J]. Journal of Veterinary Medical Science,1991,53(6):1109‑1111. [23]LI Y Y,FU S H,GUO X F,et al. Serological survey of getah virus in domestic animals in Yunnan Province,China[J]. Vector Borne and Zoonotic Diseases,2019,19(1):59‑61. [24]ZHAO M,YUE C J,YANG Z J,et al. Viral metagenomics unveiled extensive communications of viruses within giant pandas and their associated organisms in the same ecosystem[J]. Science of the Total Environment,2022,820:153317. [25]SHI N,QIU X S,CAO X Y,et al.Molecular and serological surveillance of Getah virus in the Xinjiang Uygur Autonomous Region,China,2017—2020[J].Virologica Sinica,2022,37(2):229‑237. [26]AZERIGYIK F A,FAIZAH A N,KOBAYASHI D,et al.Evaluating the mosquito host range of Getah virus and the vector competence of selected medically important mosquitoes in Getah virus transmission[J].Parasites & Vectors,2023,16(1):99. [27]SHIBATA I,HATANO Y,NISHIMURA M,et al.Isolation of Getah virus from dead fetuses extracted from a naturally infected sow in Japan[J].Veterinary Microbiology,1991,27(3/4):385‑391. [28]LIU H,HU J,LI L X,et al. Seroepidemiological investigation of Getah virus in the China‑Myanmar border area from 2022—2023[J].Frontiers in Microbiology,2023,14:1309650. [29]SHEN J Q,LIU S G,LIU S Q,et al. Genomic surveillance and evolution of Getah virus[J].Virus Evolution,2025,11(1):veaf007. [30]OLIVEIRA V H S,DÓREA F C,DEAN K R,et al.Exploring options for syndromic surveillance in aquaculture:Outbreak detection of salmon pancreas disease using production data from Norwegian farms[J].Transboundary and Emerging Diseases,2024,2024(1):9861677. [31]LAN J H,FANG M T,DUAN L L,et al. Novel porcine getah virus from diarrheal piglets in Jiangxi Province,China:Prevalence,genome sequence,and pathogenicity[J]. Animals,2024,14(20):2980. [32]SUN Q,XIE Y X,GUAN Z X,et al. Seroprevalence of Getah virus in pigs in Eastern China determined with a recombinant E2 protein‑based indirect ELISA[J].Viruses,2022,14(10):2173. [33]LAN J H,DUAN L L,LIU X Y,et al. Seroprevalence of Getah virus in pigs in Southeast China determined with a recombinant Cap protein‑based indirect ELISA[J].Frontiers in Microbiology,2025,16:1547670. [34]FUKUNAGA Y,KUMANOMIDO T,IMAGAWA H,et al. Isolation of picornavirus from horses associated with Getah virus infection[J]. Nihon Juigaku Zasshi the Japanese Journal of Veterinary Science,1981,43(4):569‑572. [35]WU Y,GAO X P,KUANG Z P,et al. Isolation and pathogenicity of a highly virulent group Ⅲ porcine Getah virus in China[J].Frontiers in Cellular and Infection Microbiology,2024,14:1494654. [36]XING C N,JIANG J F,LU Z J,et al. Isolation and characterization of Getah virus from pigs in Guangdong Province of China[J].Transboundary and Emerging Diseases,2020,67(5):2249‑2253. [37]MOU C X,MENG H,SHI K C,et al. GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis[J]. Cell Communication and Signaling,2023,21(1):361. [38]LI J L,GAO X T,LIU X J,et al. The host transcriptome change involved in the inhibitory effect of exogenous interferon‑γ on Getah virus replication[J]. Frontiers in Microbiology,2023,14:1214281. [39]SHI N,ZHU X Y,QIU X S,et al. Origin,genetic diversity, adaptive evolution and transmission dynamics of Getah virus[J]. Transboundary and Emerging Diseases,2022,69(4):e1037‑e1050. [40]QI X Y,ZHAO R H,YAO X H,et al. Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules[J]. International Journal of Biological Macromolecules,2024,279(Pt 2):135274. [41]MENG H,MOU C X,ZHANG L J,et al. The roles of 6K protein on Getah virus replication and pathogenicity[J]. Journal of Medical Virology,2023,95(12):e29302. [42]LI F Q,DENG L S,XU T,et al. Getah virus triggers ROS‑mediated autophagy in mouse Leydig cells[J].Frontiers in Microbiology,2024,15:1519694. [43]JIAN Z J,JIANG C Y,ZHU L,et al. Infectivity and pathogenesis characterization of getah virus(GETV)strain via different inoculation routes in mice[J].Heliyon,2024,10(13):e33432. [44]KUMANOMIDO T,WADA R,KANEMARU T,et al.Transplacental infection in mice inoculated with Getah virus[J]. Veterinary Microbiology,1988,16(2):129‑136.
[45]金爱华,姚龙涛,卫秀余,等. 间接血凝抑制试验检测猪盖他病抗体方法的建立和应用[J].中国兽医杂志,2000,36(9):17‑18.
[46]李向茸,冯若飞,刘俊林,等. 盖他病毒重组E2蛋白间接ELISA检测方法的建立[J].中国兽医科学,2012,42(10):1037‑1042.
[47]闵湘菱,任同伟,农作荣,等. 2016—2021年广西部分地区猪盖他病毒血清学回顾性调查[J].中国动物传染病学报,2023,31(5):145‑151.
[48]孟锦昕,何于雯,杨绍昌,等. 猪盖塔病间接ELISA检测方法的建立与应用[J].中国兽医科学,2020,50(8):962‑968. [49]YOU D,WANG Y L,GE L P,et al. Establishment and application of an indirect ELISA for Getah virus E2 antibody detection[J]. Journal of Virological Methods,2024,325:114885. [50]JIANG Z W,QIN Y,ZHANG L T,et al. Development and application of a colloidal‑gold immunochromatographic strip for detecting Getah virus antibodies[J].Applied Microbiology and Biotechnology,2024,108(1):355.
[51]王傲杰,周峰,王新港,等. 猪盖他病毒RT-PCR检测方法的建立及其应用[J].中国兽医学报,2019,39(2):209‑214.
[52]陶大鹏. 辽宁猪盖他病毒全基因组测序及诊断方法的建立[D].沈阳:沈阳农业大学,2020.
[53]王新港,周峰,王傲杰,等. 猪繁殖与呼吸综合征病毒和盖他病毒双重RT-PCR检测方法的建立与应用[J].病毒学报,2018,34(2):232‑238.
[54]关铜,岳健国,聂民财,等. 猪非典型瘟病毒和盖塔病毒双重RT-PCR方法的建立与应用[J].中国兽医科学,2021,51(2):153‑160.
[55]王傲杰. 猪盖他病毒检测方法的建立与应用及病毒的分离鉴定和序列分析[D]. 郑州:河南农业大学,2018. [56]LIN A,HU X,CUI S,et al. Development of Taqman‑based real‑time PCR assay based on the E1 genefor the quantitative detection of the Getah virus[J].Polish Journal of Veterinary Sciences,2023,26 (1):21‑28. [57]NIE M C,DENG H D,ZHOU Y C,et al. Development of a reverse transcription recombinase‑aided amplification assay for detection of Getah virus[J]. Scientific Reports,2021,11(1):20060. [58]LIU H,LI L X,BU Y P,et al. Rapid visual detection of getah virus using a loop‑mediated isothermal amplification method[J]. Vector Borne and Zoonotic Diseases,2019,19(10):741‑746. [59]LIU Z,YANG F S,FANG M T,et al. Rapid and sensitive one‑tube detection of getah virus using RT‑LAMP combined with Pyrococcus furiosus argonaute[J]. Veterinary Sciences,2025,12(2):93.
[60]NEMOTO M,BANNAI H,TSUJIMURA K,et al. Getah virus infection among racehorses,Japan,2014[J]. [61]RICO A B,PHILLIPS A T,SCHOUNTZ T,et al.Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses[J].Virology,2016,499:30‑39. [62]ATASHEVA S,KIM D Y,FROLOVA E I,et al.Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype[J].Journal of Virology,2015,89(1):71‑82. [63]FOX J M,LONG F,EDELING M A,et al. Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress[J]. Cell,2015,163 (5):1095‑1107. [64]REZZA G,CHEN R B,WEAVER S C. O’nyong‑nyong fever:A neglected mosquito‑borne viral disease[J].Pathogens and Global Health,2017,111(6):271‑275. [65]PEZZI L,RODRIGUEZ‑MORALES A J,REUSKEN C B,et al. GloPID‑R report on chikungunya,o’nyong‑nyong and Mayaro virus,part 3:Epidemiological distribution of Mayaro virus[J]. Antiviral Research,2019,172:104610. [66]FINE D L,ROBERTS B A,TEEHEE M L,et al.Venezuelan equine encephalitis virus vaccine candidate(V3526)safety,immunogenicity and efficacy in horses[J]. Vaccine,2007,25(10):1868‑1876. [67]PARTIDOS C D,PAYKEL J,WEGER J,et al.Cross‑protective immunity against o’nyong‑nyong virus afforded by a novel recombinant chikungunya vaccine[J]. Vaccine,2012,30(31):4638‑4643. [68]JIANG Z W,MERITS A,QIN Y,et al. Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses[J]. PLoS Pathogens,2024,20(11):e1012700. [69]MIAO Q H,NGUYEN W,ZHU J,et al. A getah virus‑like‑particle vaccine provides complete protection from viremia and arthritis in wild‑type mice[J].Vaccine,2024,42(25):126136. [70]VERWIMP S,WAGONER J,ARENAS E G,et al.Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo[J]. Antiviral Research,2025,239:106186. [71]LIU M Y,REN T W,ZHANG L P,et al. Development of a monoclonal antibody specifically recognizing a linear epitope on the E1 protein of Getah virus[J].Virology,2025,602:110315. [72]ZHOU L S,REN T W,LIU M Y,et al. Development of a monoclonal antibody specifically recognizing a linear epitope on the capsid protein of the emerging Group Ⅲ Getah virus[J].Virology,2024,591:109990. [73]LIU B L,WANG Y L,SHAO L N,et al. Antiviral activity of Scutellaria baicalensis Georgi Extract against Getah virus in vivo and in vitro[J]. Frontiers in Veterinary Science,2025,12:1551501. [74] REN T W,LIU M Y,ZHOU L S,et al.A recombinant Getah Virus expressing a GFP gene for rapid neutralization testing and antiviral drug screening assay[J].Virology,2024,598:110174. [75]CAI R X,HE Q,WANG Q,et al. Development of a reverse genetics system for Getah virus and characterization of rescued strains[J].Veterinary Research,2025,56(1):80. [76]JIAO H Q,YAN Z Q,ZHAI X F,et al.Transcriptome screening identifies TIPARP as an antiviral host factor against the Getah virus[J].Journal of Virology,2023,97(10):e0059123. |
| [1] | KU Chaofeng, WANG Xianwei, LÜ Lingyan, ZHANG Jiaqing, LIU Yang, SONG Weiyi, ZHANG Junxia. Effects of Artemisia argyi Powder on Growth Performance,Nutrient Apparent Digestibility,Antioxidant Function and Fecal Microbial Population in Fattening Pigs [J]. Journal of Henan Agricultural Sciences, 2025, 54(9): 141-148. |
| [2] | ZHANG Lei, YU Qingwei, LÜ Lingyan, SUN Ruyu, LIU Zheng, WANG Yanling, ZHANG Bing, DUAN Junying, ZHANG Jiaqing. Effects of Complex Plant Polysaccharides on the Body Condition Recovery,Farrowing Performance,Immune Performance of Sows and Growth Performance of Piglets [J]. Journal of Henan Agricultural Sciences, 2025, 54(8): 151-158. |
| [3] | LONG Juyan, LU Shengfei, TIAN Jiao, NIU Xi, CHEN Xia, HUANG Shihui, RAN Xueqin, WANG Jiafu. Polymorphism of Structural Variation DKK2‐I1‐sv89 in the DKK2 Gene of Five Pig Breeds [J]. Journal of Henan Agricultural Sciences, 2025, 54(4): 129-135. |
| [4] | HUANG Yuxin, WANG Wei, LI Yixing, TANG Zhonglin. The Regulatory Effect of the SP1/IGF2BP3 Axis on the Proliferation of Porcine Skeletal Muscle Satellite Cells [J]. Journal of Henan Agricultural Sciences, 2025, 54(3): 129-138. |
| [5] | SHAN Jiaye, WANG Qiuling, LI Chunguang, LI Quansheng, ZOU Shenghao, SUN Mi, LUO Dongsheng, XI Feihu, JING Yanqiu. Study on the Relationship between Chromaticity Signal Values and Plastid Pigments in Different Sections of Tobacco Leaves during Curing Process [J]. Journal of Henan Agricultural Sciences, 2025, 54(2): 163-173. |
| [6] | LI Danyang, WEI Jinhua. Estimation of Pigment Content in Leaves of Physocarpus Based on Color Parameters and Hyperspectral Parameters [J]. Journal of Henan Agricultural Sciences, 2024, 53(4): 119-127. |
| [7] | ZHANG Tao, TANG Yuanjiang, TAO Xiaoyan, LU Yuxi, ZHOU Sixuan, DU Chunlin, ZHANG Xiong, ZHANG Jing, TAN Ya, YANG Yueqian. Effects of Adding Different Rations of Qianjinqiao San on Feeding Performance of Finishing Pigs [J]. Journal of Henan Agricultural Sciences, 2024, 53(12): 159-166. |
| [8] | HAN Yuqing, BO Suxue, YAN Feifei, DUAN Mengqi, CHAMBA Yangzom, SHANG Peng. Analysis of Porcine PVALB Gene Polymorphism and Differential Expression in Muscle Tissues of Different Pig Breeds [J]. Journal of Henan Agricultural Sciences, 2023, 52(5): 150-155. |
| [9] | REN Yuansen, ZHANG Haibo, CHENG Hongyan, WANG Yumeng, LUO Yuan, LIU Na. Effect of pH Value on Acid Production Characteristics and Microbial Community in Co‐Fermentation of Pig Manure and Spent Mushroom Substrate [J]. Journal of Henan Agricultural Sciences, 2023, 52(5): 110-120. |
| [10] | LÜ Linfen, PANG Shengmei, LI Baoliang, LIANG Yuxuan, DUAN Qiangde. Research Progress of Enterotoxigenic Escherichia coli Vaccine for Piglets [J]. Journal of Henan Agricultural Sciences, 2023, 52(5): 1-8. |
| [11] | YANG Suozhou, WANG Wenwen, WANG Dan, NING Chao, WANG Yang, LI Qian, DONG Licai, GONG Weilong, LI Xin, TANG Hui. Analysis of Semen Quality and Fertilization Ability of Different Breeds of Boars [J]. Journal of Henan Agricultural Sciences, 2023, 52(4): 137-142. |
| [12] | MU Chunyu, ZHANG Rui, TANG Qingping, BU Zhu, CHANG Lingling, FU Shengyong, XIA Aiping, YANG Mingjun. Principal Component and Path Analysis of Body Size and Slaughter Performance of Different Days of Shiqi Pigeon [J]. Journal of Henan Agricultural Sciences, 2022, 51(9): 133-140. |
| [13] | LU Qingxia, WANG Ouyang, ZHANG Bin, WANG Jing, CHEN Junfeng, MA Qiang, ZHANG Jiaqing, REN Qiaoling, XING Baosong, CAO Hai. Expression Profile of Porcine SREBP‑1c Gene and Its Effect on Lipid Deposition in Intramuscular Adipocytes [J]. Journal of Henan Agricultural Sciences, 2022, 51(9): 124-132. |
| [14] | LU Hong, LI Xindi, WANG Yu, LUOBU Baizhen, DUAN Mengqi, YE Yourong, ZHANG Jian, SHANG Peng. Analysis on the Polymorphism and Tissue Expression of ANXA2 Gene in Pigs [J]. Journal of Henan Agricultural Sciences, 2022, 51(2): 120-126. |
| [15] | XING Baosong, WANG Jing, BAI Xianxiao, CHEN Junfeng, ZHANG Jiaqing, REN Qiaoling, GUO Hongxia, ZHANG Hua, CAO Hai. Influence of Different Feeding Styles on Slaughter and Meat Quality Traits of Huainan Pigs [J]. Journal of Henan Agricultural Sciences, 2021, 50(8): 160-165. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||