Study on Mechanism of Feizhu Powder for Prevention and Treatment of Deficiency of Qi and Blood in Sows Based on Network Pharmacology and Animal Experiments

doi:10.15933/j.cnki.1004-3268.2025.04.012

Journal of Henan Agricultural Sciences ›› 2025, Vol. 54 ›› Issue (4): 117-128.DOI: 10.15933/j.cnki.1004-3268.2025.04.012

• Animal Husbandry and Veterinary Medicine • Previous Articles Next Articles

Study on Mechanism of Feizhu Powder for Prevention and Treatment of Deficiency of Qi and Blood in Sows Based on Network Pharmacology and Animal Experiments

GAO Tiantian¹，LIU Xuesong²，LIU Yongti¹，QIU Zongsheng¹，LIU Yishan¹，LI Shuxin¹，QI Jingjing¹，LI Ya’nan^1,3，WEI Chengwei^1,4，MA Tianwen¹

（1.College of Veterinary Medicine，Northeast Agricultural University/Heilongjiang Province Key Laboratory of Animal Disease Pathogenesis and Comparative Medicine，Harbin 150030，China；2.Animal Husbandry and Veterinary Branch，Heilongjiang Academy of Agricultural Sciences，Qiqihar 161005，China；3.Hangzhou Baoyuan Animal Husbandry Co.，Ltd.，Hangzhou 310000，China；4.Heilongjiang Northeast Agricultural Animal Hospital，Harbin 150030，China）

Received:2024-08-17 Published:2025-04-15 Online:2025-05-20

基于网络药理和动物试验的肥猪散防治母猪气虚血亏作用机制研究

高甜甜¹，刘雪松²，刘永醍¹，裘宗盛¹，刘钇杉¹，李淑欣¹，戚晶晶¹，李亚楠^1,3，魏成威^1,4，马天文¹

（1.东北农业大学动物医学学院/黑龙江省动物疾病致病机制与比较医学重点实验室，黑龙江哈尔滨 150030；2 黑龙江省农业科学院畜牧兽医分院，黑龙江齐齐哈尔 161005；3.杭州葆元牧业有限公司，浙江杭州 310000；4.黑龙江东北农大动物医院，黑龙江哈尔滨 150030）

通讯作者: 马天文（1995-），男，黑龙江哈尔滨人，讲师，博士，主要从事动物疾病致病机制研究。E-mail：dnmatianwen@163.com
作者简介:高甜甜（1998-），女，黑龙江哈尔滨人，在读硕士研究生，研究方向：动物疾病致病机制。E-mail：1980058623@qq.com
基金资助:
黑龙江省自然科学基金项目（LH2023C025和YQ2023C015）；黑龙江省农业科学院畜牧兽医分院2022年自拟课题（ZNKT-202207）

Abstract

Abstract: In order to screen the action targets of the traditional Chinese veterinary medicine Feizhu powder for preventing and treating deficiency of Qi and blood in sows and explore its molecular mechanism，the active ingredients of the formula of Feizhu powder，their action targets，and the action targets of Qi and blood deficiency were studied，their intersection targets were obtained，and a network of the intersection targets of active ingredients of Feizhu powder and deficiency of Qi and blood was constructed. GO and KEGG pathway enrichment analysis were carried out on the intersection targets，and a network of the core ingredients and core targets and signaling pathways of Feizhu powder was constructed.Molecular docking analysis was performed on the core ingredients and core targets to screen the key targets and signaling pathways of Feizhu powder.Male KM mice were selected，and randomly divided into control group，Qi and blood deficiency model group，ferrous lactate group，and Feizhu powder group.A Qi and blood deficiency model was established for the latter three groups.The control group and Qi and blood deficiency model group were respectively intragastrically administered with 10 mL/kg normal saline，the ferrous lactate group was intragastrically administered with 10 mg/kg ferrous lactate syrup，and the Feizhu powder group was intragastrically administered with 3 g/kg Feizhu powder.The key targets and pathways of Feizhu powder for preventing and treating Qi and blood deficiency were verified through the weight‐bearing test of mice，detection of blood indexes，organ indexes，and candidate proteins.The results showed that 29 active ingredients of Feizhu powder were obtained，and 112 intersection targets of active ingredients of Feizhu powder and Qi and blood deficiency were identified.Eleven core ingredients such as daidzein，kaempferol，luteolin and β‐sitosterol were screened out，and eleven core targets such as PTGS2，PTGS1，HSP90AA1，PRKACA，and TNF were identified.The results of GO and KEGG pathway enrichment analysis showed that the active ingredients of Feizhu powder were mainly enriched in items such as binding of protein，binding of enzyme，cytoplasm，nuclear plasm，inflammatory response and response to exogenous stimuli. A total of 26 signaling pathways were enriched，including the IL‐17 pathway，the regulation of adipocyte lipolysis and the ovarian steroidogenesis pathway，etc.Molecular docking analysis results showed that the binding energies of the core ingredients and core targets were all less than -8 kcal/mol，indicating that the core ingredients and core targets had strong binding activity. The results of the mouse experiment showed that，compared with the Qi and blood deficiency model group，the weight‐bearing swimming time of mice of ferrous lactate group and Feizhu powder group significantly increased，the numbers of white blood cells and red blood cells and the hemoglobin content all significantly increased；the spleen index and thymus index all significantly increased，and the protein expression levels of IL‐17 and TNF‐α in the spleen tissues all significantly decreased.In conclusion，the core ingredients of the traditional Chinese veterinary medicine Feizhu powder are daidzein，kaempferol，luteolin，β‐sitosterol，etc.，and the core targets are PTGS2，PTGS1，HSP90AA1，PRKACA，TNF，etc.，which play important roles in preventing and treating Qi and blood deficiency in sows through signaling pathways such as IL‐17.

Key words: Sow, Feizhu powder, Deficiency of Qi and blood, Action targets, IL‐17 signaling pathway, Network pharmacology

摘要： 为了筛选传统中兽药肥猪散防治母猪气虚血亏的作用靶点并探究其分子机制，研究肥猪散组方的有效成分及其作用靶点、气虚血亏作用靶点，获取交集靶点，构建肥猪散有效成分-气虚血亏交集靶点网络图；对交集靶点进行GO功能和KEGG通路富集分析，构建肥猪散核心成分-核心靶点-信号通路网络；对核心成分和核心靶点进行分子对接分析，筛选肥猪散关键靶点和信号通路；选取雄性KM小鼠，随机分为对照组、气血双虚模型组、乳酸亚铁组和肥猪散组，对后3组构建气血双虚模型，对照组和气血双虚模型组分别用10 mL/kg生理盐水灌胃，乳酸亚铁组用10 mg/kg乳酸亚铁糖浆灌胃，肥猪散组用3 g/kg肥猪散灌胃，进行小鼠负重试验、血液指标检测、脏器指数测定、候选蛋白检测，验证肥猪散防治母猪气虚血亏的关键靶点和通路。结果表明，获得肥猪散有效成分29种，肥猪散有效成分-气虚血亏交集靶点112个。筛选出大豆苷元、山奈酚、木犀草素和β-谷甾醇等核心成分11种，PTGS2、PTGS1、HSP90AA1、PRKACA和TNF等核心靶点11个。GO功能和KEGG通路富集分析结果表明，肥猪散的活性成分主要富集于蛋白质结合、酶结合、细胞质、核质、炎症反应和外源性刺激反应等条目；共富集到26条信号通路，包括IL-17通路、脂肪细胞分解调控和卵巢类固醇通路等。分子对接分析发现，核心成分和核心靶点的结合能均小于-8 kcal/mol，表明核心成分和核心靶点具有强烈结合活性。小鼠负重试验结果表明，与气血双虚模型组相比，乳酸亚铁组和肥猪散组小鼠的负重游泳时间均极显著提高；白细胞、红细胞数量和血红蛋白含量均极显著上升；脾脏指数和胸腺指数均极显著提高；脾脏组织中IL-17和TNF-α蛋白表达量均极显著降低。综上，传统中兽药肥猪散的核心成分为大豆苷元、山奈酚、木犀草素和β-谷甾醇等，核心靶点为PTGS2、PTGS1、HSP90AA1、PRKACA和TNF等，通过IL-17等信号通路在防治母猪气虚血亏过程中发挥重要作用。

关键词: 母猪, 肥猪散, 气虚血亏, 作用靶点, IL-17信号通路, 网络药理学

CLC Number:

S828
S853

GAO Tiantian, LIU Xuesong, LIU Yongti, QIU Zongsheng, LIU Yishan, LI Shuxin, QI Jingjing, LI Ya’nan, WEI Chengwei, MA Tianwen. Study on Mechanism of Feizhu Powder for Prevention and Treatment of Deficiency of Qi and Blood in Sows Based on Network Pharmacology and Animal Experiments[J]. Journal of Henan Agricultural Sciences, 2025, 54(4): 117-128.

高甜甜, 刘雪松, 刘永醍, 裘宗盛, 刘钇杉, 李淑欣, 戚晶晶, 李亚楠, 魏成威, 马天文1. 基于网络药理和动物试验的肥猪散防治母猪气虚血亏作用机制研究[J]. 河南农业科学, 2025, 54(4): 117-128.

Figures/Tables 13

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Study on Mechanism of Feizhu Powder for Prevention and Treatment of Deficiency of Qi and Blood in Sows Based on Network Pharmacology and Animal Experiments

基于网络药理和动物试验的肥猪散防治母猪气虚血亏作用机制研究

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