河南农业科学 ›› 2022, Vol. 51 ›› Issue (10): 9-16.DOI: 10.15933/j.cnki.1004-3268.2022.10.002

• 综述 • 上一篇    下一篇

MicroRNA 在杆状病毒侵染过程中的功能研究进展

张小霞,孙笑颜,杨艳青,王秋云,梁振普   

  1. (河南农业大学生命科学学院,河南 郑州 450002)
  • 收稿日期:2022-04-27 出版日期:2022-10-15 发布日期:2022-12-12
  • 通讯作者: 梁振普(1976-),男,河南濮阳人,教授,博士,主要从事昆虫病毒分子生物学研究。E-mail:lzpbio@126.com
  • 作者简介:张小霞(1973-),女,河南济源人,教授,博士,主要从事昆虫病毒分子生物学研究。E-mail:lzpzxx@126.com
  • 基金资助:
    国家自然科学基金项目(31570151);河南省高等学校重点科研项目(19A210004);河南省重点科技攻关项目(202102110222);南疆重点产业创新发展支撑计划项目(2022DB026)

Research Progress in the Function of MicroRNA in the Process of Baculovirus Infection

ZHANG Xiaoxia,SUN Xiaoyan,YANG Yanqing,WANG Qiuyun,LIANG Zhenpu   

  1. (College of Life Science,Henan Agricultural University,Zhengzhou 450002,China)
  • Received:2022-04-27 Published:2022-10-15 Online:2022-12-12

摘要: MicroRNA(miRNA)是一类由内源基因编码的非编码RNA,约22 nt,是基因表达的关键调节因子,参与生物体中一系列重要的生物学过程。大多数DNA病毒编码miRNA,包括杆状病毒。杆状病毒由双链环状DNA组成,能特异性感染鳞翅目、膜翅目和双翅目等昆虫,在农业害虫防治和生物学研究中广泛应用。介绍了miRNA的生物合成和作用机制,并综述了杆状病毒感染宿主后病毒和昆虫宿主编码的miRNA以及其在杆状病毒侵染过程中的功能,为杆状病毒杀虫剂的研发和应用提供理论依据。

关键词: 微小RNA, 杆状病毒, 昆虫宿主, 昆虫-杆状病毒互作, 基因调控

Abstract: MicroRNAs(miRNAs)are a class of non‑coding RNAs encoded by endogenous genes,about 22 nt,which are key regulators of gene expression and participate in a series of important biological processes in organisms.Most DNA viruses encode miRNA,including baculovirus. The baculovirus consists of double‑stranded circular DNA,can specifically infect insects of Lepidoptera,Hymenoptera and Diptera,and has been widely used in agricultural pest control and biological research.The biosynthesis and functional mechanism of miRNAs were introduced in the paper,and virus‑ and host‑encoded miRNAs after baculovirus infection of hosts and the functions of miRNAs in the process of baculovirus infection were reviewed,which can provide a theoretical basis for the development and application of baculovirus insecticides.

Key words: miRNA, Baculovirus, Insect host, Insect?baculovirus interaction, Gene regulation

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