[1]MAFFEI M,HALAAS J,RAVUSSIN E,et al.Leptin levels in human and rodent:Measurement of plasma leptin and ob RNA in obese and weight‑reduced subjects[J].Nat Med,1995,1:1155‑1161.
[2]ZHANG Y,PROENCA R,MAFFEI M,et al.Positional cloning of the mouse obese gene and its human homologue[J].Nature,1994,372:425‑432.
[3 ]HO‑PHAM L T,LAI T Q,NGUYEN U D,et al.Delineating the relationship between leptin,fat mass,and bone mineral density:A mediation analysis[J].Calcified Tissue International,2017,100(1):13‑19.
[4]MYERS M G,LEIBE R L,SEELEY R J,et al.Obesity and leptin resistance:Distinguishing cause from effect[J].Trends Endocrinol Metab,2010,21(11):643‑651.
[5]PEELMAN F,ZABEAU L,MOHARANA K,et al.20 years of leptin:Insights into signaling assemblies of the leptin recepto[r J].J Endocrinol,2014,223(1):9‑23.
[6]LIU W,ZHOU X,LI Y,et al.Serum leptin,resistin,and adiponectin levels in obese and non‑obese patients with newly diagnosed type 2 diabetes mellitus:A population‑based study[J].Medicine(Baltimore),2020,99(6):e19052.
[7]ZHAO S,LI N,ZHU Y,et al.Partial leptin deficiency confers resistance to diet‑induced obesity in mice[J].Mol Metab,2020,37:100995.
[8]SCHNEIDER J E. Energy balance and reproduction[J].Physiol Behav,2004,81(2):289‑317.
[9]YADAV T,MAGOTRA A,KUMAR R,et al.Evaluation of candidate genotype of leptin gene associated with fertility and production traits in Hardhenu(Bos taurus ×Bos indicus)cattle[J].Reprod Domest Anim,2020,55(12):1698‑1705.
[10]WANG X,ZHANG X,HU L,et al.Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice[J].Reprod Biol Endocrinol,2018,16(1):55.
[11]PANDA B S K,PANDEY S,SOMAL A,et al.Leptin supplementation in vitro improved developmental competence of buffalo oocytes and embryos[J].Theriogenology,2017,98:116‑122.
[12]KUMAR P,SAINI M,KUMAR D,et al.Quantification of leptin in seminal plasma of buffalo bulls and its correlation with antioxidant status,conventional and computer‑assisted sperm analysis (CASA) semen variables[J].Anim Reprod Sci,2016,166:122‑127.
[13]CLEMENT F.Multiscale mathematical modeling of the hypothalamo‑pituitary‑gonadal axis[J].Theriogenology,2016,86(1):11‑21.
[14]MERCATI F,DALLAGLIO C,TIMPERI L,et al.Epithelial expression of the hormone leptin by bovine skin[J].Eur J Histochem,2019,63(1):2993.
[15]ZIEBA D A,BIERNAT W,SZCZESNA M,et al.Changes in expression of the genes for the leptin signaling in hypothalamic‑pituitary selected areas and endocrine responses to long‑term manipulation in body weight and resistin in ewes[J].Int J Mol Sci,2020,21 (12):4238.
[16]GARCIA M R,AMSTALDEN M,WILLIAMS S W,et al.Serum leptin and its adipose gene expression during pubertal development,the estrous cycle,and different seasons in cattle[J].J Anim Sci,2002,80 (8):2158‑2167.
[17]陈强.转基因鸡生物反应器生产人瘦素蛋白的研究[D].扬州:扬州大学,2009.
CHEN Q.Researching on the human leptin by transgenic chicken bioreactors[D].Yangzhou:Yangzhou University,2009. [18]ZHANG Q,XU D,ZHANG M,et al.Construction and analysis of an adipose tissue‑specific and methylation‑sensitive promoter of leptin gene[J].Appl Biochem Biotechnol,2016,180(6):1213‑1226.
[19]庞礴,于鸿浩,张湑泽,等.高原鼠兔瘦素蛋白乳腺特异表达载体的构建及细胞表达[J].兽类学报,2019,39(1):84‑93.
PANG B,YU H H,ZHANG X Z,et al.Construction of mammary gland‑specific expression vector for plateau pika(Ochotona curzoniae)leptin gene and its expressionin cells[J].Acta Theriologica Sinica,2019,39(1):84‑93.
[20]周朋君,马岩岩,王一飞,等.人瘦素基因的原核表达载体构建及其蛋白结构分析[J].广东药学院学报,2016,32(3):355‑361.
ZHOU P J,MA Y Y,WANG Y F,et al.Construction of leptin gene expression vector and analysis of its protein structure[J].Journal of Guangdong Pharmaceutical University,2016,32(3):355‑361.
[21]LIU F,SONG Y,LIU D. Hydrodynamics‑based transfection in animals by systemic administration of plasmid DNA[J].Gene Ther,1999,6(7):1258‑1266.
[22]ARAD U,ZEIRA E,ELLATIF M A,et al.Liver‑targeted gene therapy by SV40‑based vectors using the hydrodynamic injection method[J].Hum Gene Ther,2005,16(3):361‑371.
[23]FRIEDMAN J M.Leptin and the endocrine control of energy balance[J].Nat Metab,2019,1(8):754‑764.
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