In order to develop long-lasting repellent for ticks, four repellent formulations with 20% IR3535 content were designed. According to the physical and chemical characteristics of IR3535,with IR3535 as active component, absolute ethanol as solvent, α-pyrrolidone as stabilizer, PEG-400 as tackifier,PVP-K30, CMC-Na and maltodextrin as slow-release components combined in a variety of solvent systems to design.The results of stability test showed that the solvent formulation with 5%—20%PVP,5%—20% α-pyrrolidone,5%—20% PEG-400 and 30% anhydrous ethanol had the best stability.The content of mosquito repellent was determined by gas chromatography.The results showed that the average intra day precision was 0. 59%,the average inter day precision were 0.49%,and the average recovery was 97.4%.The content of three batches of long-acting repellent was between 98.1% and 103.8% of the labeled amount.To sum up,the preparation of IR3535 long-acting tick repellent agent is simple,stable and repeatable.