In order to realize the sustainable development of green ecological production of grape,four fertilization modes,CF(farmers’ habitual fertilization,three times application),RF(30% reduction of CF,three times application),SF(nitrogen,phosphorus reduction and potassium increase of CF,two times application),RSF(30% reduction of SF,two times application),were set up by field experiments to study the effects of reducing fertilization amount and frequency on Shine Muscat grape yield,nutrient uptake and soil nutrient residue. The results showed that RF, SF and RSF could increase the fresh fruit yield compared with CF and decrease the water content of grapes, increase the absorption of nitrogen,phosphorus and potassium in leaves,reduce the residue of nitrate nitrogen in one meter soil profile.SF and RSF could significantly increase soil available potassium residue in 60 cm soil profile.Among them,RF was the best fertilization mode,which increased the fresh weight of grape fruit by 3.1%,decreased the moisture content by 1.0 percentage points,increased the absorption of nitrogen,phosphorus and potassium of leaves by 13.9%,22.7%,14.0%,increased the absorption of potassium of fruit by 2.5%,decreased nitrate nitrogen residue in 1-meter soil by 16.4%,and decreased available phosphorus and potassium residues by 16.6% and 12.7% in 60 cm soil profile.Therefore,reasonable reduced fertilization can not only reduce fertilizer input and production cost,but also increase grape yield and nutrient absorption,reduce soil nutrient residue,and can be applied in production.