低温不仅制约植物的生长与发育，也制约植物的种植分布。为了应对低温伤害，植物通过改变基因表达和细胞内环境稳态来维持机体存活。CBF(C-repeat binding transcription factor)在植物响应低温胁迫中发挥枢纽作用，通过调控下游冷响应基因COR(Cold regulated)等的表达，提高植物对低温的耐受能力。对CBF的功能及其调控的下游基因、调控CBF基因的上游基因、CBF与激素互作等方面进行综述，并展望了CBF在农业生产上的应用前景，为深入研究CBF的耐冷机制奠定基础，为利用基因工程技术培育耐冷作物品种提供参考。

Low temperature not only limits the growth and development of plants,but also limits the distribution of plants.To reduce the damage induced by low-temperature stress,plants evolve many mechanisms to resist cold stress through changing gene expression level and cellular environmental homeostasis.CBF(C-repeat binding transcription factor) plays critical roles in response to low temperature stress,and improves cold tolerance by altering the expression of cold regulated genes(COR).The functions of CBF and downstream genes regulated by CBF,the upstream genes that regulated CBF gene,and the interaction between CBF and hormones were reviewed,and the application prospect of CBF in agricultural production was raised.This review can lay the foundation for future study of crop cold tolerance mechanism,and provide theoretical reference for breeding of cold tolerant crops by gene engineering.