转录因子KLF家族的结构、功能及调控机制研究进展

河南农业科学 ›› 2019, Vol. 48 ›› Issue (7): 1-5.

转录因子KLF家族的结构、功能及调控机制研究进展

杨堤贻¹，张子敬²，王大会³，安清明³，王二耀²，王献伟⁴，雷初朝¹，陈宏¹，黄永震¹

（1.西北农林科技大学动物科技学院，陕西杨凌 712100； 2.河南省农业科学院畜牧兽医研究所，河南郑州 450002；3.铜仁学院农林工程与规划学院，贵州铜仁 554300； 4.河南省畜牧总站，河南郑州 450008）

收稿日期:2018-12-23 出版日期:2019-07-15 发布日期:2019-07-15
通讯作者: 黄永震（1982-），男，河南南阳人，副教授，博士，主要从事动物遗传与育种研究。E-mail:hyzsci@nwafu.edu.cn
作者简介:杨堤贻（1998-），女，山西太原人，在读本科生，研究方向：动物遗传育种与繁殖。E-mail:ydy98318@163.com
基金资助:
国家自然科学基金青年科学基金项目（31601926）；河南省科技攻关计划项目（172102110084，182102110023）；贵州省科技计划项目（2018-2277，2018-1161）；国家肉牛牦牛产业技术体系专项（CARS-37）

Received:2018-12-23 Published:2019-07-15 Online:2019-07-15

摘要/Abstract

摘要： 转录因子KLF家族（Krüppellike factors）成员的C-末端区域中均存在3个保守的Cys2/His2锌指结构，它们能够参与调控真核生物的多种生理过程并发挥重要作用，包括促进脂肪组织和肌肉形成、影响神经系统发育、参与肿瘤发生过程、调控细胞和组织及系统水平的代谢和修复损伤的代谢组织等，是当前生物领域的研究热点。因此，综述了KLF家族成员的共同结构特征，以及KLF3、KLF5、KLF6、KLF7、KLF8、KLF14、KLF15的主要生理功能及其调控机制的研究进展，为未来进一步探讨KLF家族转录因子的作用和相关疾病的分子机制提供参考。

杨堤贻，张子敬，王大会，安清明，王二耀，王献伟，雷初朝，陈宏，黄永震. 转录因子KLF家族的结构、功能及调控机制研究进展[J]. 河南农业科学, 2019, 48(7): 1-5.

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